Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism

Ling Xiao*, Dario F. De Jesus*, Cheng-Wei Ju*, Jiang-Bo Wei, Jiang Hu, Ava DiStefano-Forti, Valeria Salerno Gonzales, Tadataka Tsuji, Siying Wei, Matthias Blüher, Yu-Hua Tseng, Chuan He, Rohit N. Kulkarni

Nature Communications, 2025

m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation.

S. Kahraman*, Dario F. De Jesus*, Jiangbo Wei, Natalie K Brown, Zhongyu Zou, Jiang Hu, M. Pirouz, Richard I Gregory, Chuan He, Rohit N. Kulkarni

EMBO Journal, 2024

m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.

Ling Xiao*, Dario F. De Jesus*, C. Ju*, J. Wei, Jiang Hu, Ava DiStefano-Forti, Tadataka Tsuji, C. Cero, V. Männistö, Suvi M Manninen, Siying Wei, Oluwaseun Ijaduola, Matthias Blüher, A. Cypess, J. Pihlajamäki, Yu-Hua Tseng, C. He, Rohit N. Kulkarni

Cell Metabolism, 2024

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.

Dario F De Jesus, Zijie Zhang, Natalie K Brown, Xiaolu Li, Ling Xiao, Jiang Hu, Matthew J. Gaffrey, Garrett Fogarty, S. Kahraman, Jiangbo Wei, G. Basile, Tariq M Rana, Clayton E. Mathews, Alvin C. Powers, Audrey V Parent, Mark A. Atkinson, S. Dhe-Paganon, D. Eizirik, Wei-Jun Qian, Chuan He, Rohit N. Kulkarni

Nature Cell Biology, 2024

NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes.

Dario F. De Jesus, Tomohiko Kimura, Manoj K. Gupta, R. Kulkarni

Cell Chemical Biology, 2023

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice.

Dario F. De Jesus, K. Orime, D. Kamińska, Tomohiko Kimura, G. Basile, Chih-Hao Wang, Larissa Haertle, Renzo J M Riemens, Natalie K Brown, Jiang Hu, V. Männistö, A. Silva, E. Dirice, Y. Tseng, T. Haaf, J. Pihlajamäki, R. Kulkarni

Journal of Clinical Investigation, 2020

m6A mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes

Dario F. De Jesus*, Zijie Zhang*, S. Kahraman*, Natalie K Brown, Mengjie Chen, Jiang Hu, Manoj K. Gupta, Chuan He, R. Kulkarni

Nature Metabolism, 2019